- FIRST APATITE-PEPTIDE NANOPARTICLES FOR NANOMEDICINE

Hybrid apatite NPs decorated with bioactive peptides through one-pot controlled synthesis



Doi: 10.1002/smll.202306358

Abstract at a glance: "In this work, we report the first preparation of hybrid apatite NPs decorated by bioactive peptides, obtained via a one-pot synthesis process. Such nano-objects are very appealing for nanomedicine and open a wide range of potential applications as in wound healing. We report also here a thorough characterization of the particles through a large set of complementary techniques such as XRD, FTIR, Raman, liquid and solid state NMR, TEM, DLS and chemical analyses. Apatite NPs can thus be possibly used as a novel platform to fix bioactie peptides whose properties (antimicrobial, prohealing...) can be selected in view of the envisioned clinical application. "

- TPMS GYROID POROUS STRUCTURES FOR BONE REPAIR

Highly-percolating 3D scaffolds with TPMS Gyroid cellular porous structure: a pilot study



Doi: 10.1016/j.actbio.2023.08.041

Abstract at a glance: "TPMS Gyroid porous structures are particularly appealing for the production of 3D porous scaffolds with highly-percolating features, somewhat reminind those of natural trabecular bone. Only rare in vivo outcomes were accessible for extended periods of time and in a large animal model. In this pilot study, we demonstrate for the first time in these conditions the relevance of such structures for a hydroxyapatite composition."

- CORE-SHELL PARTICLES FOR SUBSEQUENT ACTIONS IN VIVO

Novel core-shell bioinspired particles with controlled spatial distribution of bioactive ions for subsequent releases



Doi: 10.3390/nano13030519

Abstract at a glance: "We developed a strategy based on freeze-drying to obtain dually-substituted core-shell microparticles to be distributed in bone substitutes in view of subsequent releases and sequential actions after implantation, typically antibacterial first, then pro-angiogenic/osteogenic."

- SAFE-BY-DESIGN ANTIBACTERIAL BIOMATERIALS

Innovative peroxide-doped biomimetic apatites for tropical dentistry and beyond



Doi: 10.3390/jfb13030144

Abstract at a glance: "We prepared and evaluated from a physicochemical and biological viewpoint some innovative peroxide-doped biomimetic apatites, as such and included in 3D porous scaffolds obtained by freeze-casting. Both the apatite support and the peroxide ions (close to ROIs used naturally in vivo to fight against pathogens) may be seen as bio-inspired leading to a safe-by-design global approach."

- BIO-ACTIVATED BONE SUBSTITUTES

How to bio-activate existing/commercial bi-phasic calcium phophates using high pressure CO2...



Doi: 10.3390/ma15207306

Abstract at a glance: "We demonstrate how to bio-activate some initially poorly-bioactive HA/beta-TCP scaffolds upon treatment under supercritical CO2. We explain the underlying mechanisms, thus generating a novel "coating from" approach that was validated by selected biological evaluations."

- NEW ENGINEERED 3D SCAFFOLDS OF LDHs

Successful preparation of cohesive scaffolds of Layered Double Hydroxides (LDHs) now made possible by cold sintering



Doi: 10.1016/j.mseb.2022.115704

Abstract at a glance: "We investigated the consolidation of Layered Double Hydroxides (LDH) by cold sintering to fabricate, for the first time, some cohesive 3D scaffolds. We demonstrate that our approach can be applied to several LDH compositions including biocompatible ones, and examined the scaffold properties via both an experimental and computational (DFT) approach. Obtaining cohesive LDH scaffolds is now possible, opening a wealth of applications as in catalysis, energy, depollution and healthcare."

- ONCOLOGY

Localized treatment of osteosarcoma



Doi: 10.2217/fon-2021-0128

Abstract at a glance: "A proof of concept is established using a bone cement formulation associated with biomimetic apatite particles functionalized with doxorubicin to treat osteosarcoma and limit metastasis. First in vivo data are given on an invasive rodent model."

- ENGINEERED AMORPHOUS BONE SUBSTITUTES

Cold sintering of ACP: towards highly resorbable bone substitutes



Doi: 10.1039/C9TB02121C

Abstract at a glance: "For the first time, amorphous calcium phosphate (ACP) has been successfully consolidated via cold sintering while preserving its amorphous character, providing highly-resorbable bone repair compounds."

- DERMATOLOGY

Limiting the skin penetration of drugs for dermatology applications via smart bio-inspired apatite particles



Doi: 10.1016/j.actbio.2020.05.010

Abstract at a glance: ""We demonstrate that colloidal apatites may be used as biocompatible drug carriers to favor a surface (topical) delivery/effect for dermatology applications, while limiting the undesirable penetration of the isolated drug and related side-effects".

- VIROLOGY

Nanotechnologies including calcium phosphates play a key role in virus fight



Doi: 10.26717/BJSTR.2020.27.004500

Abstract at a glance: "Nanosystems offer a wealth of possibilities for fighting against pathogens such as viruses. Inorganic particles are particularly suitable for various usages. Among them, CaPs are appealing bio-inspired and tailorable compounds for use in virus fight."

- SMART SYSTEMS IN NANOMEDICINE

Colloidal apatite particles: a multifunctional platform in (nano)medicine



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Abstract at a glance: "Colloidal bio-inspired apatite particles may be decorated by a wealth of organic species and contain selected active ions to provide a wide range of functionalities for use in (nano)medicine as in dermatology, hematology, oncology, medical imaging.".

- HEMATOLOGY

Bio-inspired apatite nanoparticles for red blood cell cryopreservation



Doi: 10.1016/j.biomaterials.2017.06.018

Abstract at a glance: "We demonstrate that bio-inspired apatite-based hybrid nanoparticles drastically improve red blood cells (RBC) cryopreservation by mediating trehalose delivery via an enhanced membrane permeation effect".

- ANTHROPOLOGY

Adsorption of DNA on biomimetic apatites: Toward the understanding of the role of bone and tooth mineral on the preservation of ancient DNA



Doi: 10.1016/j.apsusc.2013.12.063

Abstract at a glance: "DNA is a phosphated macromolecule. Its preservation from skeletal remains (teeth, bones) over time (paleo-anthropology) could be related to its quantitative adsorption to bone/teeth apatite crystals after cell lysis/during diagenesis, thus conveying some protection to DNA strands".

- MARS MINERALOGY

Apatite minerals on Mars: distant characterization by LIBS and preparation of an OH-Cl-F apatite standard to fly to Mars aboard the Perseverance rover (TAPAG calibration target landed on Mars in Feb. 2021)



Doi: 10.1007/s11214-020-00764-w

Abstract at a glance: "Apatite minerals have been identified on Mars surface by previous rover missions. A series of apatite standards has been prepared by C. Drouet and one sample has been sent, among the other calibration targets, to Mars aboard the Perseverance rover (NASA) in views of in situ LIBS calibration."

Press extracts:

• - [Open Access News / openaccessgovernment.org]
  The advent of biomimetic apatites in today's and tomorrow's medicine
  
  
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• - [Open Access News / medicineinnovates.com]
  Toward smart self-accumulating bio-inspired drug carriers for improved topical efficacy in dermatology
  
  
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• - [Open Access News / Innovationnewsnetwork.com]
  Modifying calcium phosphate-based materials for bone repair
  
  
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