My present research themes mainly concern (nano)materials for Health applications, and particularly
biomaterials for bone tissue engineering and fully biocompatible colloidal nanoparticles for cellular interaction for
either therapeutic or diagnosis applications.
Principal research axes :
- - Physico-chemical investigation of nanocrystalline apatites analogous to bone mineral: characterization of non-apatitic chemical environments on the surface of apatite nanocrystals (presence of a surface hydrated layer), volume and surface properties, follow-up of biological properties.
- - Development of a new generation of « low temperature » bioactive and biodegradable bioceramics: Study of the consolidation of calcium phosphates by non-conventional techniques: application of Spark Plasma Sintering to nanocrystalline apatites. Physico-chemical and biological properties of the prepared bioceramics.
- - Surface ion exchanges / Associations with drugs and active compounds: : ion exchange with biologically-active ions (Mg2+, Sr2+, HPO42-, CO32-...), study of the reversibility of the exchange, exchange isotherms, adsorption capacity, association with (and release of) active compounds (growth factors, antibiotics, anti-cancerous drugs...).
- - Development of colloidal nanoparticles based on biomimetic calcium phosphates for applications in therapeutics and for diagnosis purposes (cancers…); new colloidal luminescent nanoprobes in view of cell targeting.
- - Soft chemistry (« Chimie douce ») and control of calcium phosphate particle morphology.
- - Study of the thermodynamic properties of nanocrystalline apatites analogous to bone minerals, consequences for biomineralization phenomena.
- - Functionalization of the surface of existing biomaterials; organic/inorganic interfaces.
- - Study of the nucleation and growth of calcium phosphates on biomaterials based on metal (titanium…) or ceramics ; bioactive coatings.
© 2008 All right reserved • Christophe Drouet • Conception CREA2F